Article
Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.
Cancer research - 15 Sept 1994
Chen K G, Jaffrézou J P, Fleming W H, Durán G E, Sikic B I
Abstract excerpt
Fluctuation analysis experiments were performed in the human sarcoma cell line MES-SA to assess whether selection or induction mechanisms determine resistance to doxorubicin (DOX), mutation rates, and the nature of the surviving clones. Thirteen flasks were seeded with 2000 cells/flask and grown...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antimetabolites, Antineoplastic
- Base Sequence
- Carrier Proteins
- DNA Topoisomerases, Type II
- Doxorubicin
- Drug Resistance
- Glutathione
- Humans
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Phenotype
- Rhodamine 123
- Rhodamines
- Sarcoma
- Vinblastine