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Article

Vaults Are Up-regulated in Multidrug-resistant Cancer Cell Lines

1 Apr 1998

Abstract excerpt

Vaults are 13-MDa ribonucleoprotein particles composed largely of a 104-kDa protein, termed major vault protein or MVP, and a small vault RNA, vRNA. While MVP levels have been found to increase up to 15-fold in non-P-glycoprotein multidrug-resistant cell lines, the levels of vault particles have not been investigated. As both the function of vault particles and the mechanism of drug resistance in...

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PMID: 9535882
DOI: 10.1074/jbc.273.15.8971

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