Article
Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
The Journal of biological chemistry - 28 Feb 1997
Chen G, Durán G E, Steger K A, Lacayo N J, Jaffrézou J P, Dumontet C, Sikic B I
Abstract excerpt
A variant of the multidrug-resistant human sarcoma cell line Dx5 was derived by co-selection with doxorubicin and the cyclosporin D analogue PSC 833, a potent inhibitor of the multidrug transporter P-glycoprotein. The variant DxP cells manifest an altered phenotype compared with Dx5, with decreas...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Affinity Labels
- Azides
- Blotting, Western
- Cell Survival
- Cyclosporins
- DNA Topoisomerases, Type II
- Dihydropyridines
- Doxorubicin
- Drug Resistance, Multiple
- Humans
- Neoplasm Proteins
- Phenotype
- Polymerase Chain Reaction
- Prazosin
- Rhodamine 123
- Rhodamines
- Sarcoma