Article
Characterization of a multidrug resistant human erythroleukemia cell line (K562) exhibiting spontaneous resistance to 1-beta-D-arabinofuranosylcytosine.
Leukemia - 1 May 1995
Grant S, Turner A, Nelms P, Yanovich S
Abstract excerpt
We have assessed the response of a previously characterized multidrug resistant (MDR) human erythroleukemia cell line (K562R) to the nucleoside analog antimetabolite 1-beta-D-arabinofuranosylcytosine (ara-C). This cell line has been subjected to selection pressure by intermittent exposure to daunorubicin, but not ara-C, since its initial isolation. In comparison to the parental line (K562S), K562R were...
Topics
- Arabinofuranosylcytosine Triphosphate
- Cytarabine
- DNA, Neoplasm
- Deoxycytidine Kinase
- Drug Resistance, Multiple
- Humans
- Leukemia, Erythroblastic, Acute
- Phenotype
- Thymidine
- Tritium
- Tumor Cells, Cultured