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Article

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.

eLife - 27 Apr 2021

Sanborn Adrian L, Yeh Benjamin T, Feigerle Jordan T, Hao Cynthia V, Townshend Raphael Jl, Lieberman Aiden Erez, Dror Ron O, Kornberg Roger D

Abstract excerpt

Gene activator proteins comprise distinct DNA-binding and transcriptional activation domains (ADs). Because few ADs have been described, we tested domains tiling all yeast transcription factors for activation in vivo and identified 150 ADs. By mRNA display, we showed that 73% of ADs bound the Med15 subunit of Mediator, and that binding strength was correlated with activation. AD-Mediator interaction in vitro was...

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Identifiers

PMID: 33904398
DOI: 10.7554/eLife.68068
PMCID: PMC8137143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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