Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders.

European journal of haematology - 1 Aug 2000

Aggerholm A, Grønbaek K, Guldberg P, Hokland P

Abstract excerpt

The candidate tumour suppressor gene MMAC1/PTEN located at chromosome 10q23.3 has been reported to be frequently mutated in a number of solid tumours. Less is known about its status in leukaemia. In the present study we first analysed 13 leukaemia cell lines for mutations and homozygous deletions in MMAC1/PTEN using PCR and denaturing gradient gel electrophoresis (DGGE). We identified an intragenic deletion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electrophoresis, Agar Gel
Share to HL-60 Cells
Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Myelodysplastic Syndromes

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to U937 Cells

Source

Identifiers

PMID: 10966170
DOI: 10.1034/j.1600-0609.2000.90181.x

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders.PMID 10966170Read ↗

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemiaSemantic proximity Read ↗

Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract.Semantic proximity Read ↗

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.Semantic proximity Read ↗

Analysis of PTEN/MMAC1 alteration in neuroblastoma.Semantic proximity Read ↗

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.Semantic proximity Read ↗

Investigation of MMAC/PTEN gene mutations and protein expression in low grade gliomas.Semantic proximity Read ↗

Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas.Semantic proximity Read ↗

PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.Semantic proximity Read ↗

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.Semantic proximity Read ↗

Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Semantic proximity Read ↗

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.