Article
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.
Oncogene - 15 Oct 1998
Dong J T, Sipe T W, Hyytinen E R, Li C L, Heise C, McClintock D E, Grant C D, Chung L W, Frierson H F
Abstract excerpt
Deletion of the q23-24 region of human chromosome 10 is one of the most frequent genetic alterations in prostate cancer, suggesting that inactivation of a tumor suppressor gene in this region is involved in the development or progression of this carcinoma. A candidate gene, PTEN/MMAC1, has been i...
Topics
- Adult
- Aged
- Base Sequence
- DNA Primers
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Loss of Heterozygosity
- Male
- Middle Aged
- Mutation
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Prostatic Neoplasms
- Protein Tyrosine Phosphatases
- Sequence Deletion
- Tumor Suppressor Proteins