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Article

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.

Oncogene - 15 Oct 1998

Dong J T, Sipe T W, Hyytinen E R, Li C L, Heise C, McClintock D E, Grant C D, Chung L W, Frierson H F

Abstract excerpt

Deletion of the q23-24 region of human chromosome 10 is one of the most frequent genetic alterations in prostate cancer, suggesting that inactivation of a tumor suppressor gene in this region is involved in the development or progression of this carcinoma. A candidate gene, PTEN/MMAC1, has been identified from this chromosomal region; mutations of this gene have been found in various advanced tumors and cell...

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Source

Identifiers

PMID: 9788441
DOI: 10.1038/sj.onc.1202119

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.PMID 9788441Read ↗

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.Semantic proximity Read ↗

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.Semantic proximity Read ↗

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.Semantic proximity Read ↗

Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract.Semantic proximity Read ↗

Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

Absence of PTEN germ-line mutations in men with a potential inherited predisposition to prostate cancer.Semantic proximity Read ↗

Somatic mutation of PTEN in bladder carcinoma.Semantic proximity Read ↗

Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines.Semantic proximity Read ↗

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.Semantic proximity Read ↗

Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.Semantic proximity Read ↗

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors.Semantic proximity Read ↗

Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis.Semantic proximity Read ↗

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