Article
Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas.
Oncology reports - 1 Jan 2000
Papp T, Schipper H, Pemsel H, Unverricht M, Muller K M, Wiethege T, Schiffmann D, Rahman Q
Abstract excerpt
Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not frequently involved in mesothelioma formation.
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