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Article

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.

Journal of the National Cancer Institute - 17 Nov 1999

Ali I U, Schriml L M, Dean M

Abstract excerpt

PTEN/MMAC1 (phosphatase, tensin homologue/mutated in multiple advanced cancers) is a tumor suppressor protein that has sequence homology with dual-specificity phosphatases, which are capable of dephosphorylating both tyrosine phosphate and serine/threonine phosphate residues on proteins. The in vivo function of PTEN/MMAC1 appears to be dephosphorylation of phosphotidylinositol 3,4, 5-triphosphate. The PTEN/MMAC1...

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Source

Identifiers

PMID: 10564676
DOI: 10.1093/jnci/91.22.1922

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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