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Article

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

Cancer research - 1 Sept 1997

Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin A F, Zeuthen J

Abstract excerpt

The MMAC1/PTEN gene, located at 10q23.3, is a candidate tumor suppressor commonly mutated in glioma. We have studied the pattern of deletion, mutation, and expression of MMAC1/PTEN in 35 unrelated melanoma cell lines. Nine (26%) of the cell lines showed partial or complete homozygous deletion of...

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Source

Identifiers

PMID: 9288767

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9288767-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.PMID 9288767Read ↗

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Investigation of MMAC/PTEN gene mutations and protein expression in low grade gliomas.Semantic proximity Read ↗

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.Semantic proximity Read ↗

Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases.Semantic proximity Read ↗

PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo.Semantic proximity Read ↗

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