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Article

PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

Cancer research - 1 Dec 1997

Liu W, James C D, Frederick L, Alderete B E, Jenkins R B

Abstract excerpt

Loss of heterozygosity (LOH) from chromosome 10 is a hallmark of glioblastoma, the most malignant (grade IV) form of glioma. A candidate tumor suppressor gene, PTEN/MMAC1, that may be targeted for deletion in association with chromosome 10 LOH has recently been identified. Here we have investigated 63 glioblastomas for PTEN/MMAC1 alterations and identified DNA sequence changes that would affect the encoded...

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Source

Identifiers

PMID: 9393744

Genes

PTEN
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.PMID 9393744Read ↗

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Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.Semantic proximity Read ↗

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