Article
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Cancer research - 1 Dec 1997
Teng D H, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen K L, Vinson V L, Gumpper K L, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford L A, Lee J, Mills G B, Pershouse M A, Pollack R E, Tornos C, Troncoso P, Yung W K, Fujii G, Berson A, Steck P A
Abstract excerpt
A candidate tumor suppressor gene, MMAC1/PTEN, located in human chromosome band 10q23, was recently identified based on sequence alterations observed in several glioma, breast, prostate, and kidney tumor specimens or cell lines. To further investigate the mutational profile of this gene in human...
Topics
- Brain Neoplasms
- Breast Neoplasms
- Child
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- Exons
- Female
- Gene Deletion
- Genetic Markers
- Genetic Variation
- Glioblastoma
- Glioma
- Humans
- Introns