Article
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Cancer research - 1 Dec 1997
Teng D H, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen K L, Vinson V L, Gumpper K L, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford L A, Lee J, Mills G B, Pershouse M A, Pollack R E, Tornos C, Troncoso P, Yung W K, Fujii G, Berson A, Steck P A
Abstract excerpt
A candidate tumor suppressor gene, MMAC1/PTEN, located in human chromosome band 10q23, was recently identified based on sequence alterations observed in several glioma, breast, prostate, and kidney tumor specimens or cell lines. To further investigate the mutational profile of this gene in human cancers, we examined a large set of human tumor specimens and cancer cell lines of many types for 10q23 allelic losses...
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