Article
Analysis of PTEN/MMAC1 alteration in neuroblastoma.
Cancer genetics and cytogenetics - 1 Mar 2001
Moritake H, Horii Y, Kuroda H, Sugimoto T
Abstract excerpt
Neuroblastoma is the most common extracranial solid tumor in children. Although it has been reported that loss of heterozygosity at various loci, including 10q, frequently occurs in neuroblastoma, a bona fide tumor suppressor gene has not been identified. Recently, a gene mapped to chromosome 10q23, PTEN/MMAC1, was identified as a tumor suppressor gene that inhibits cell survival and cell proliferation by...
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