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Article

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia

1 Apr 2000

Abstract excerpt

Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in a number of cancer cell lines and primary cancers. Mutations in PTEN/MMAC1 are most frequently found in advanced cancers. To evaluate...

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PMID: 10706759
DOI: 10.1002/(sici)1096-8652(200004)63:4<170::aid-ajh2>3.0.co;2-0

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