Article
Somatic mutation of PTEN in vulvar cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2000
Holway A H, Rieger-Christ K M, Miner W R, Cain J W, Dugan J M, Pezza J A, Silverman M L, Shapter A, McLellan R, Summerhayes I C
Abstract excerpt
PTEN, a candidate tumor suppressor gene located at chromosome 10q23.3, has been shown to be mutated in approximately 40% of endometrial cancers. Such mutations have also been identified in endometrial hyperplasia, indicating that inactivation of the PTEN tumor suppressor gene is an early event in the genesis of some endometrial cancers. In this study, we have extended the analysis of PTEN in gynecological cancer...
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