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Article

In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells.

Nucleic acids research - 1 Sept 2000

Smith S A, Engelward B P

Abstract excerpt

3-Methyladenine (3MeA) DNA glycosylases initiate base excision repair by removing 3MeA. These glycosylases also remove a broad spectrum of spontaneous and environmentally induced base lesions in vitro. Mouse cells lacking the Aag 3MeA DNA glycosylase (also known as the Mpg, APNG or ANPG DNA glycosylase) are susceptible to 3MeA-induced S phase arrest, chromosome aberrations and apoptosis, but it is not known if...

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Identifiers

PMID: 10954597
DOI: 10.1093/nar/28.17.3294
PMCID: PMC110696

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