Article

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

2021-01-13

Abstract excerpt

<h4>Summary</h4> N -nitrosodimethylamine (NDMA) is a DNA methylating agent that has been discovered to contaminate water, food and drugs. The alkyladenine glycosylase (AAG) removes methylated bases to initiate the base excision repair (BER) pathway. To understand how gene-environment interactions impact disease susceptibility, we studied Aag −/− and Aag -overexpressing mice that harbor increased levels of eithe...

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Literature Corpus work: 5c708b48-ebba-599b-9170-414cdc0ddcb6
DOI: 10.1101/2021.01.12.426356

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