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Article

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.

Cell reports - 16 Mar 2021

Kay Jennifer E, Corrigan Joshua J, Armijo Amanda L, Nazari Ilana S, Kohale Ishwar N, Torous Dorothea K, Avlasevich Svetlana L, Croy Robert G, Wadduwage Dushan N, Carrasco Sebastian E, Dertinger Stephen D, White Forest M, Essigmann John M, Samson Leona D, Engelward Bevin P

Abstract excerpt

N-Nitrosodimethylamine (NDMA) is a DNA-methylating agent that has been discovered to contaminate water, food, and drugs. The alkyladenine DNA glycosylase (AAG) removes methylated bases to initiate the base excision repair (BER) pathway. To understand how gene-environment interactions impact disease susceptibility, we study Aag-knockout (Aag-/-) and Aag-overexpressing mice that harbor increased levels of either...

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Identifiers

PMID: 33730582
DOI: 10.1016/j.celrep.2021.108864
PMCID: PMC8527524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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