Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer.

doi:10.1016/j.dnarep.2026.103955

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Article

Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer.

DNA repair - 1 Oct 2026

Kay Jennifer E, Corrigan Joshua J, Volk Lindsay B, Armijo Amanda L, Owiti Norah A, Pribyl Lee J, Nazari Ilana S, Torous Dorothea K, Avlasevich Svetlana L, Croy Robert G, Wadduwage Dushan N, Carrasco Sebastian E, Dertinger Stephen D, Essigmann John M, Samson Leona D, Engelward Bevin P

Abstract excerpt

N-Nitrosodimethylamine (NDMA) is present in food, water, and drugs and is considered a probable human carcinogen by the International Agency for Research on Cancer. The mechanism of action of NDMA involves the generation of carcinogenic methyl lesions such as 3-methyladenine (3MeA) on DNA bases. Alkyladenine DNA Glycosylase (AAG; a.k.a. N-methylpurine DNA glycosylase, MPG) removes 3MeA to initiate Base Excision...

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Topics

Animals
Male
Female
Excision Repair
DNA Glycosylases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Mice

Dimethylnitrosamine

Alkylation

Liver Neoplasms

Liver

Sex Factors

DNA Damage

Source

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Identifiers

PMID: 42566817
DOI: 10.1016/j.dnarep.2026.103955
PMCID: PMC13613344

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