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Article

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 1999

Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, Epe B, Seeberg E, Lindahl T, Barnes D E

Abstract excerpt

DNA damage generated by oxidant byproducts of cellular metabolism has been proposed as a key factor in cancer and aging. Oxygen free radicals cause predominantly base damage in DNA, and the most frequent mutagenic base lesion is 7,8-dihydro-8-oxoguanine (8-oxoG). This altered base can pair with A...

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Source

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Identifiers

PMID: 10557315
DOI: 10.1073/pnas.96.23.13300
PMCID: PMC23942

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10557315-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.PMID 10557315Read ↗

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Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.Semantic proximity Read ↗

High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress.Semantic proximity Read ↗

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Drosophila Ogg1 is required to suppress 8-oxo-guanine accumulation following oxidative stress.Semantic proximity Read ↗

Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis.Semantic proximity Read ↗

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