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Article

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.

Molecular and cellular biology - 1 Oct 1998

Elder R H, Jansen J G, Weeks R J, Willington M A, Deans B, Watson A J, Mynett K J, Bailey J A, Cooper D P, Rafferty J A, Heeran M C, Wijnhoven S W, van Zeeland A A, Margison G P

Abstract excerpt

Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse transcription-PCR and by the inability of cell extracts of tissues from the knockout (ko) animals to release 3-methyladenine (3-meA) or 7-methylguanine (7-meG) from 3H-methylated calf thymus DNA in vitro. Following...

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Identifiers

PMID: 9742100
DOI: 10.1128/MCB.18.10.5828
PMCID: PMC109169

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