Article
Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.
Molecular and cellular biology - 1 Oct 1998
Elder R H, Jansen J G, Weeks R J, Willington M A, Deans B, Watson A J, Mynett K J, Bailey J A, Cooper D P, Rafferty J A, Heeran M C, Wijnhoven S W, van Zeeland A A, Margison G P
Abstract excerpt
Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse transcription-PCR and by the inability of cell extracts of tissues from the knockout (ko) animals to re...
Topics
- Animals
- Bone Marrow Cells
- Cells, Cultured
- DNA Glycosylases
- Dacarbazine
- Erythrocytes
- Ethylnitrosourea
- Female
- Fibroblasts
- Guanine
- Hypoxanthine Phosphoribosyltransferase
- Leukocyte Count
- Liver
- Male