Article

Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer

2025-05-14

Abstract excerpt

<h4>ABSTRACT</h4> N -Nitrosodimethylamine (NDMA) is present in food, water, and drugs and is considered a probable human carcinogen by the International Agency for Research on Cancer. The mechanism of action of NDMA involves the generation of carcinogenic methyl lesions such as 3-methyladenine (3MeA) on DNA bases. Alkyladenine DNA Glycosylase (AAG) removes 3MeA to initiate Base Excision Repair, leaving an interme...

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Literature Corpus work: 106a72fd-85bf-5b5e-8695-96f4e1a80780
DOI: 10.1101/2025.05.13.653839

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