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Article

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997

Engelward B P, Weeda G, Wyatt M D, Broekhof J L, de Wit J, Donker I, Allan J M, Gold B, Hoeijmakers J H, Samson L D

Abstract excerpt

3-methyladenine (3MeA) DNA glycosylases remove 3MeAs from alkylated DNA to initiate the base excision repair pathway. Here we report the generation of mice deficient in the 3MeA DNA glycosylase encoded by the Aag (Mpg) gene. Alkyladenine DNA glycosylase turns out to be the major DNA glycosylase not only for the cytotoxic 3MeA DNA lesion, but also for the mutagenic 1,N6-ethenoadenine (epsilonA) and hypoxanthine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9371804
DOI: 10.1073/pnas.94.24.13087
PMCID: PMC24267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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