Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines.

British journal of cancer - 1 Sept 2000

Tonetti D A, Chisamore M J, Grdina W, Schurz H, Jordan V C

Abstract excerpt

An inverse relationship between protein kinase C (PKC) activity and oestrogen receptor (ER) expression in human breast cell lines and tumours has been firmly established over the past 10 years. To determine whether specific alterations in PKC expression accompany hormone-independence, we examined the expression of PKC isozymes in the hormone-independent human breast cancer cell clones MCF-7 5C and T47D:C42...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Hormonal
Share to Clone Cells
Share to Mice, Nude

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms, Hormone-Dependent

Share to Protein Kinase C

Share to Protein Kinase C-alpha

Share to Receptors, Estrogen

Share to Tamoxifen

Source

Open in PubMed Open full text

Identifiers

PMID: 10952784
DOI: 10.1054/bjoc.2000.1326
PMCID: PMC2363523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines.PMID 10952784Read ↗

Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model.Semantic proximity Read ↗

Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.Semantic proximity Read ↗

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.Semantic proximity Read ↗

Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells.Semantic proximity Read ↗

Protein kinase C and its isoforms in human breast cancer cells: relationship to the invasive phenotype.Semantic proximity Read ↗

Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta.Semantic proximity Read ↗

Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells.Semantic proximity Read ↗

Identification of four novel phosphorylation sites in estrogen receptor α: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2Semantic proximity Read ↗

Contribution of individual PKC isoforms to breast cancer progression.Semantic proximity Read ↗

Modification of gene expression induced by siRNA targeting of estrogen receptor α in MCF7 human breast cancer cellsSemantic proximity Read ↗

Overexpression of protein kinase Calpha in MCF-10A human breast cells engenders dramatic alterations in morphology, proliferation, and motility.Semantic proximity Read ↗

Quantification of <i>PKC</i> family genes in sporadic breast cancer by qRT‐PCR: Evidence that <i>PKC</i>ι/λ overexpression is an independent prognostic factorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.