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Quantification of <i>PKC</i> family genes in sporadic breast cancer by qRT‐PCR: Evidence that <i>PKC</i>ι/λ overexpression is an independent prognostic factor

17 Apr 2012

Abstract excerpt

Drugs targeting protein kinase C (PKC) show promising therapeutic activity. However, little is known about the expression patterns of the 11 PKC genes in human tumors, and the clinical significance of most PKC genes is unknown. We used qRT-PCR assays to quantify mRNA levels of the 11 PKC genes in 458 breast tumors from patients with known clinical/pathological status and long-term outcome. The proportion of...

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PMID: 22511072
DOI: 10.1002/ijc.27600

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