Article
Protein kinase C and its isoforms in human breast cancer cells: relationship to the invasive phenotype.
International journal of oncology - 1 Jun 1998
Morse-Gaudio M, Connolly J M, Rose D P
Abstract excerpt
Total protein kinase C (PKC) activity and the expression of 9 isoforms were determined in the estrogen receptor (ER) positive MCF-7 human breast cancer cell line, this line transfected to overexpress either PKC-á or erbB2, and in 3 ER negative breast cancer cell lines. Relationships were sought between PKC and the expression of E-cadherin, alpha-catenin, and vimentin, and urokinase-type plasminogen activator...
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