Article
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.
The Journal of clinical investigation - 1 Apr 1995
Ways D K, Kukoly C A, deVente J, Hooker J L, Bryant W O, Posekany K J, Fletcher D J, Cook P P, Parker P J
Abstract excerpt
Increased protein kinase C (PKC) activity in malignant breast tissue and positive correlations between PKC activity and expression of a more aggressive phenotype in breast cancer cell lines suggest a role for this signal transduction pathway in the pathogenesis and/or progression of breast cancer...
Topics
- Animals
- Blotting, Northern
- Blotting, Western
- Breast Neoplasms
- Cell Adhesion
- Cell Cycle
- Female
- Humans
- Isoenzymes
- Mammary Neoplasms, Experimental
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Invasiveness