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Article

Contribution of individual PKC isoforms to breast cancer progression.

IUBMB life - 1 Jan 2012

Urtreger Alejandro J, Kazanietz Marcelo G, Bal de Kier Joffé Elisa D

Abstract excerpt

The protein kinase C (PKC) family of serine/threonine kinases has been intensively studied in cancer since their discovery as major receptors for the tumor-promoting phorbol esters. The contribution of each individual PKC isozyme to malignant transformation is only partially understood, but it is clear that each PKC plays different role in cancer progression. PKC deregulation is a common phenomenon observed in...

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PMID: 22095874
DOI: 10.1002/iub.574

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