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Article

Modification of gene expression induced by siRNA targeting of estrogen receptor α in MCF7 human breast cancer cells

1 Jan 1992

Abstract excerpt

To establish a model of endocrine resistant breast cancer that is associated with loss of estrogen receptor (ER), MCF7 cells were transfected with several plasmid constructs intended to produce intracellular double stranded hairpin RNA to be processed into siRNA directed against different regions of the ERalpha mRNA. Stably transformed cells were propagated in long-term culture. One of these lines, designated...

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PMID: 19082494
DOI: 10.3892/ijo_00000145

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