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Article

Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta.

European journal of biochemistry - 1 Aug 2001

Gill P K, Gescher A, Gant T W

Abstract excerpt

Increased levels of the protein kinase C (PKC) isoenzymes alpha and theta occur in conjunction with MDR1 gene expression in cells and tissues that have acquired a multidrug resistance (MDR) phenotype. Studies using PKC activators or antisense strategies against PKC suggest that activation of PKC engenders MDR1 gene transcription. In this study the potential roles of PKC-alpha and PKC-theta in MDR1 gene...

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PMID: 11488907
DOI: 10.1046/j.1432-1327.2001.02326.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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