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Article

Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Daniel Andrea R, Lange Carol A

Abstract excerpt

In advanced breast tumors, protein kinases are upregulated and steroid hormone receptors often function independently of ligand. Herein, we explored mechanisms of ligand-independent progesterone receptor (PR) activity. We showed previously that growth factor-induced phosphorylation of PR Ser-294 blocks PR Lys-388 sumoylation. SUMO-deficient mutant PR-B (K388R) thus provides a model receptor for the study of PR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19706513
DOI: 10.1073/pnas.0905118106
PMCID: PMC2732858

Genes

STC1
CDK2
EGF
HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells.PMID 19706513Read ↗

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