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Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1996

Manni A, Buckwalter E, Etindi R, Kunselman S, Rossini A, Mauger D, Dabbs D, Demers L

Abstract excerpt

To address the isoenzyme-specific involvement of protein kinase C (PKC) in breast cancer biology, hormone-responsive MCF-7 breast cancer cells were infected with either PKC-alpha or -beta 1 cDNAs subcloned in the retroviral expression vector pMV7. Several stable clones of PKC-overexpressing cells were generated. Western analysis revealed cross-regulation between the alpha and beta isoforms, because induction of...

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PMID: 8877100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.PMID 8877100Read ↗

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