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Article

Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males.

Neuroscience - 5 Dec 2007

Hebda-Bauer E K, Luo J, Watson S J, Akil H

Abstract excerpt

Age-related changes in the hippocampus increase vulnerability to impaired learning and memory. Our goal is to understand how a genetic vulnerability to cognitive impairment can be modified by aging and sex. Mice with a mutation in the cAMP response element binding (CREB) protein gene (CREB(alphadelta-) deficient mice) have a mild cognitive impairment and show test condition-dependent learning and memory deficits....

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Source

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Identifiers

PMID: 18029102
DOI: 10.1016/j.neuroscience.2007.09.019
PMCID: PMC2278026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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