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Article

Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.

Science (New York, N.Y.) - 2 Aug 1996

Maldonado R, Blendy J A, Tzavara E, Gass P, Roques B P, Hanoune J, Schütz G

Abstract excerpt

Chronic morphine administration induces an up-regulation of several components of the cyclic adenosine 5'-monophosphate (cAMP) signal transduction cascade. The behavioral and biochemical consequences of opiate withdrawal were investigated in mice with a genetic disruption of the alpha and Delta i...

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Identifiers

PMID: 8662559
DOI: 10.1126/science.273.5275.657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8662559-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.PMID 8662559Read ↗

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