Article
Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine.
Journal of neurochemistry - 1 Nov 2010
Parlato Rosanna, Cruz Hans, Otto Christiane, Murtra Patricia, Parkitna Jan Rodriguez, Martin Miquel, Bura Simona A, Begus-Nahrmann Yvonne, von Bohlen und Halbach Oliver, Maldonado Rafael, Schütz Günther, Lüscher Christian
Abstract excerpt
Repeated exposure to opiates leads to cellular and molecular changes and behavioral alterations reflecting a state of dependence. In noradrenergic neurons, cyclic AMP (cAMP)-dependent pathways are activated during opiate withdrawal, but their contribution to the activity of locus coeruleus noradr...
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