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Article

Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2002

Nakagawa Shin, Kim Ji-Eun, Lee Rena, Malberg Jessica E, Chen Jingshan, Steffen Cathy, Zhang Ya-Jun, Nestler Eric J, Duman Ronald S

Abstract excerpt

The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade on neurogenesis in adult hippocampus was determined. Activation of the cAMP cascade by administration of rolipram, an inhibitor of cAMP breakdown, increased the proliferation of newborn cells in adult mouse hippocampus. In...

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Identifiers

PMID: 11978843
PMCID: PMC6758358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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