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Article

Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development.

Molecular and cellular biology - 1 Sept 2000

Esteban L M, Fernández-Medarde A, López E, Yienger K, Guerrero C, Ward J M, Tessarollo L, Santos E

Abstract excerpt

The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in transmission of signals initiated by surface protein tyrosine kinases that are transduced into the cell through the action of membrane-associated Ras proteins. Recent reports showed that targeted disruption of the sos1 locus...

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Identifiers

PMID: 10938118
DOI: 10.1128/MCB.20.17.6410-6413.2000
PMCID: PMC86116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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