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Article

SOS GEFs in health and disease.

Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2020

Baltanás Fernando C, Zarich Natasha, Rojas-Cabañeros Jose M, Santos Eugenio

Abstract excerpt

SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins contain a sequence of modular domains that are responsible for different intramolecular and intermolecular interactions modulating mechanisms of self-inhibition, allosteric activation and intracellular homeostasis. Despite their homology,...

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PMID: 33035641
DOI: 10.1016/j.bbcan.2020.188445

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