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Article

Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.

Molecular and cellular biology - 1 Apr 2002

Fernández-Medarde Alberto, Esteban Luis M, Núñez Alejandro, Porteros Angel, Tessarollo Lino, Santos Eugenio

Abstract excerpt

The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system tissues. Such similarities raise questions concerning the specificity and/or redundancy at the fu...

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Identifiers

PMID: 11909944
DOI: 10.1128/MCB.22.8.2498-2504.2002
PMCID: PMC133706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11909944-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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