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Article

Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.

The EMBO journal - 3 Jul 2000

Chang C, Hopper N A, Sternberg P W

Abstract excerpt

Vulval induction in Caenorhabditis elegans has helped define an evolutionarily conserved signal transduction pathway from receptor tyrosine kinases (RTKs) through the adaptor protein SEM-5 to RAS. One component present in other organisms, a guanine nucleotide exchange factor for Ras, has been missing in C.ELEGANS: To understand the regulation of this pathway it is crucial to have all positive-acting components in...

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Identifiers

PMID: 10880441
DOI: 10.1093/emboj/19.13.3283
PMCID: PMC313952

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.PMID 10880441Read ↗

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