Article
The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.
Science signaling - 12 Nov 2013
Kortum Robert L, Balagopalan Lakshmi, Alexander Clayton P, Garcia Julie, Pinski John M, Merrill Robert K, Nguyen Phan H, Li Wenmei, Agarwal Isha, Akpan Itoro O, Sommers Connie L, Samelson Lawrence E
Abstract excerpt
The activation of the small guanosine triphosphatase Ras by the guanine nucleotide exchange factor (GEF) Sos1 (Son of Sevenless 1) is a central feature of many receptor-stimulated signaling pathways. In developing T cells (thymocytes), Sos1-dependent activation of extracellular signal-regulated kinase (ERK) is required to stimulate cellular proliferation and differentiation. We showed that in addition to its GEF...
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