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Article

Hematopoietic and neural crest defects in zebrafish shoc2 mutants: a novel vertebrate model for Noonan-like syndrome.

Human molecular genetics - 1 Feb 2019

Jang HyeIn, Oakley Erin, Forbes-Osborne Marie, Kesler Melissa V, Norcross Rebecca, Morris Ann C, Galperin Emilia

Abstract excerpt

The extracellular signal-related kinase 1 and 2 (ERK1/2) pathway is a highly conserved signaling cascade with numerous essential functions in development. The scaffold protein Shoc2 amplifies the activity of the ERK1/2 pathway and is an essential modulator of a variety of signaling inputs. Germline mutations in Shoc2 are associated with the human developmental disease known as the Noonan-like syndrome with loose...

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Identifiers

PMID: 30329053
DOI: 10.1093/hmg/ddy366
PMCID: PMC6337701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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