Article
The Grb2 binding domain of mSos1 is not required for downstream signal transduction.
Nature genetics - 1 Jul 1995
Wang W, Fisher E M, Jia Q, Dunn J M, Porfiri E, Downward J, Egan S E
Abstract excerpt
Cellular Ras proteins are activated primarily by specific guanine-nucleotide releasing factors such as the Son of Sevenless (Sos) proteins. This activation event is thought to occur in response to plasma membrane localization of a complex containing Sos and a small adapter protein Grb2. We have i...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- Frameshift Mutation
- GRB2 Adaptor Protein
- Guanine Nucleotide Exchange Factors
- Models, Biological
- Molecular Sequence Data
- Polymerase Chain Reaction
- Protein Binding
- Proteins
- Rats
- Signal Transduction