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Article

The Grb2 binding domain of mSos1 is not required for downstream signal transduction.

Nature genetics - 1 Jul 1995

Wang W, Fisher E M, Jia Q, Dunn J M, Porfiri E, Downward J, Egan S E

Abstract excerpt

Cellular Ras proteins are activated primarily by specific guanine-nucleotide releasing factors such as the Son of Sevenless (Sos) proteins. This activation event is thought to occur in response to plasma membrane localization of a complex containing Sos and a small adapter protein Grb2. We have isolated a dominant mutant allele of mSos1 which transforms Rat1 cells, yet is no longer able to bind Grb2. Biochemical...

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PMID: 7670467
DOI: 10.1038/ng0795-294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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