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Article

Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade.

The Journal of biological chemistry - 13 Oct 2000

Woo C H, Eom Y W, Yoo M H, You H J, Han H J, Song W K, Yoo Y J, Chun J S, Kim J H

Abstract excerpt

Reactive oxygen species (ROS) are important regulatory molecules implicated in the signaling cascade triggered by tumor necrosis factor (TNF)-alpha, although the events through which TNF-alpha induces ROS generation are not yet well characterized. We therefore investigated selected candidates likely to mediate TNF-alpha-induced ROS generation. Consistent with the role of Rac in that process, stable expression of...

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Identifiers

PMID: 10934206
DOI: 10.1074/jbc.M005638200

Genes

TNF
LTB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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