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Article

Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades.

Journal of neurochemistry - 1 Jul 2010

Sun Hu-Nan, Kim Sun-Uk, Huang Song Mei, Kim Jin-Man, Park Young-Ho, Kim Seok-Ho, Yang Hee-Young, Chung Kyoung-Jin, Lee Tae-Hoon, Choi Hoon Sung, Min Ju Sik, Park Moon-Ki, Kim Sang-Keun, Lee Sang-Rae, Chang Kyu-Tae, Lee Sang-Ho, Yu Dae-Yeul, Lee Dong-Seok

Abstract excerpt

Reactive oxygen species (ROS) actively participate in microglia-mediated pathogenesis as pro-inflammatory molecules. However, little is known about the involvement of specific antioxidants in maintaining the microglial oxidative balance. We demonstrate that microglial peroxiredoxin (Prx) 5 expression is up-regulated by lipopolysaccharide (LPS) through activation of the ROS-sensitive signaling pathway and is...

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Identifiers

PMID: 20345759
DOI: 10.1111/j.1471-4159.2010.06691.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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