Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2000

Ozaki M, Deshpande S S, Angkeow P, Bellan J, Lowenstein C J, Dinauer M C, Goldschmidt-Clermont P J, Irani K

Abstract excerpt

Reperfusion of ischemic tissue results in the generation of reactive oxygen species that contribute to tissue injury. The sources of reactive oxygen species in reperfused tissue are not fully characterized. We hypothesized that the small GTPase Rac1 mediates the oxidative burst in reperfused tissue and thereby contributes to reperfusion injury. In an in vivo model of mouse hepatic ischemia/reperfusion injury,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lipid Peroxidation
Share to NADPH Oxidase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH Oxidases

Share to Necrosis

Share to NF-kappa B

Share to Phagocytes

Share to rac1 GTP-Binding Protein

Share to Reperfusion Injury

Source

Identifiers

PMID: 10657998
DOI: 10.1096/fasebj.14.2.418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo.PMID 10657998Read ↗

Inactivation of the small GTPase Rac1 protects the liver from ischemia/reperfusion injury in the rat.Semantic proximity Read ↗

Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury.Semantic proximity Read ↗

New insights into ischemia-reperfusion injury signaling pathways in organ transplantationSemantic proximity Read ↗

Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury.Semantic proximity Read ↗

The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injurySemantic proximity Read ↗

Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells.Semantic proximity Read ↗

Double-Stranded RNA Dependent Protein Kinase (PKR) Deficiency Protects the Liver Against Ischemia/reperfusion InjurySemantic proximity Read ↗

Implication of the small GTPase Rac1 in the apoptosis induced by UV in Rat-2 fibroblasts.Semantic proximity Read ↗

Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2.Semantic proximity Read ↗

Targeted disruption of peroxiredoxin 6 gene renders the heart vulnerable to ischemia-reperfusion injury.Semantic proximity Read ↗

NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.Semantic proximity Read ↗

Protective Effect of Peroxiredoxin 6 in Ischemia/Reperfusion-Induced Damage of Small Intestine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.