Article
Rac mediates growth factor-induced arachidonic acid release.
Cell - 16 Jun 1995
Peppelenbosch M P, Qiu R G, de Vries-Smits A M, Tertoolen L G, de Laat S W, McCormick F, Hall A, Symons M H, Bos J L
Abstract excerpt
Growth factor-induced stress fiber formation involves signal transduction through Rac and Rho proteins and production of leukotrienes from arachidonic acid metabolism. In exploring the relationship between these pathways, we found that Rac is essential for EGF-induced arachidonic acid production...
Topics
- 3T3 Cells
- Actins
- Animals
- Arachidonate 5-Lipoxygenase
- Arachidonic Acid
- Cell Line
- Cytoskeleton
- Epidermal Growth Factor
- GTP-Binding Proteins
- Leukotrienes
- Membrane Proteins
- Mice
- Mutation
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins c-akt
- Rats
- Signal Transduction
- rhoB GTP-Binding Protein