Article
Rac mediates growth factor-induced arachidonic acid release.
Cell - 16 Jun 1995
Peppelenbosch M P, Qiu R G, de Vries-Smits A M, Tertoolen L G, de Laat S W, McCormick F, Hall A, Symons M H, Bos J L
Abstract excerpt
Growth factor-induced stress fiber formation involves signal transduction through Rac and Rho proteins and production of leukotrienes from arachidonic acid metabolism. In exploring the relationship between these pathways, we found that Rac is essential for EGF-induced arachidonic acid production and subsequent generation of leukotrienes and that Rac V12, a constitutively activated mutant of Rac, generates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.