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Article

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS).

The Journal of experimental medicine - 14 Mar 2011

Bulua Ariel C, Simon Anna, Maddipati Ravikanth, Pelletier Martin, Park Heiyoung, Kim Kye-Young, Sack Michael N, Kastner Daniel L, Siegel Richard M

Abstract excerpt

Reactive oxygen species (ROS) have an established role in inflammation and host defense, as they kill intracellular bacteria and have been shown to activate the NLRP3 inflammasome. Here, we find that ROS generated by mitochondrial respiration are important for normal lipopolysaccharide (LPS)-driven production of several proinflammatory cytokines and for the enhanced responsiveness to LPS seen in cells from...

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Source

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Identifiers

PMID: 21282379
DOI: 10.1084/jem.20102049
PMCID: PMC3058571

Genes

NLRP3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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