Article
Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway.
Molecular immunology - 1 Mar 2009
Chen Bing-Chang, Kang Ju-Chiun, Lu Yen-Ta, Hsu Ming-Jen, Liao Chiao-Chun, Chiu Wen-Ta, Yeh Fu-Lung, Lin Chien-Huang
Abstract excerpt
Previously, we found that peptidoglycan (PGN), a cell wall component of the gram-positive bacterium Staphylococcus aureus, may activate the Ras/Raf-1/extracellular signal-regulated kinase (ERK) pathway, which in turn initiates IkappaB kinases alpha/beta (IKKalpha/beta) and nuclear factor-kappaB (NF-kappaB) activation, and ultimately induces cyclooxygenase-2 (COX-2) expression in RAW 264.7 macrophages. In this...
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