Article
Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B.
The Journal of biological chemistry - 10 Aug 2001
Sanlioglu S, Williams C M, Samavati L, Butler N S, Wang G, McCray P B, Ritchie T C, Hunninghake G W, Zandi E, Engelhardt J F
Abstract excerpt
Reactive oxygen species (ROS) are important second messengers generated in response to many types of environmental stress. In this setting, changes in intracellular ROS can activate signal transduction pathways that influence how cells react to their environment. In sepsis, a dynamic proinflammatory cellular response to bacterial toxins (e.g. lipopolysaccharide or LPS) leads to widespread organ damage and death....
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